Раздел содержит 28 соединений с подтверждённой чистотой ≥95%. Каждый продукт сопровождается сертификатом анализа (CoA), паспортом безопасности (SDS) на русском языке и поддержкой по подбору.
Heparin, named after its discovery in the liver, is a mucopolysaccharide sulfate composed of glucosamine, L-idosaccharide, n-acetylglucosamine and D-glucuronic acid, with an average molecular weight o
FDL-169 is a novel and мощный CFTR (Cystic fibrosis transmembrane conductance regulator) corrector being developed by Flatley Discovery Lab for treating cystic fibrosis (CF) patients who carry the F50
AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists.
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Emprumapimod is a мощный, orally bioavailable and селективный ингибитор of p38α MAPK directly inhibits LPS-induced IL-6 production from RPMI-8226 клетка (IC50=100 pM). Emprumapimod can be used for the
5-HT2A рецептор агонист-3 is the most селективный агонист for the human 5-HT2A рецептор yet discovered, with a Ki of 2.5 nM, and with 124-fold selectivity for 5-HT2A over the structurally similar 5-HT
BMS-502 is a dual DGKα and ζ ингибитор. BMS-502 demonstrated dose-dependent immune stimulation in the mouse OT-1 model, setting the stage for a препарат discovery program.
RLY-2608 is an oral allosteric pan-mutant isoform-селективный PI3K伪 ингибитор that was discovered using MD modeling and cryo-EM to identify allosteric networks and opportunities for small molecules, f
EN106 is a мощный ингибитор of FEMIB. EN106 targets FEM1B, an E3 ligase recently discovered as the critical component of the клеточный response to reductive stress. By targeting C186 in FEM1B, EN106 d
GSK481 is a Highly мощный and Monoselective рецептор Interacting Protein 1 киназы ингибитор (RIP1 ингибитор). The recent discovery of the role of рецептор interacting protein 1 (RIP1) киназы in tumor
SB02024 is a novel highly мощный, селективный, ATP competitive, orally active ингибитор of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times селективный towards other PI3K isoenzymes; S
HCH6-1 is a competitive антагонист of Formyl peptide рецептор 1 (FPR1), an emerging therapeutic target for the discovery of drugs to treat neutrophilic inflammatory diseases. HCH6-1 is a селективный F
AAK1-IN-1(BMS-986176) is a chemical probe for AAK1 and BIKE that potently targets the ATP-связывание site (AAK1 Ki = 9.1 nM; BIKE Ki = 17 nM). Regarding киназы selectivity, only three kinases were obs
TCB-32 (Compound I-1) is a FGFR1 агонист with an EC50 of 0.88 μM. TCB-32 significantly increases клетка proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK 1/2 with
Leucinostatin H is a polypeptide antibiotic discovered in Paecilomyces marquandii, characterized by a tertiary amine-oxide terminal group. Leucinostatin H exhibits inhibitory activity against Gram-pos
Polymyxin D2 is an antibiotic discovered from Bacillus polymyxa, exhibiting antibacterial activity. Its core structure consists of a cyclic heptapeptide moiety and a tripeptide side chain with a fatty
Fasudil, also known as HA-1077, is a мощный Rho-киназы ингибитор and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid
Novel highly мощный and селективный ингибитор (type 1.5 связывание mode) of MAPK14 [IC50 = 0.2 nM (ELISA, клетка free); KD = 1.5 nM (DiscoverX)]
Novel activator of BtGH84, the first experimentally discovered малая молекула activator of a glycoside hydrolase
GW461484A (GW-461484A) is a мощный малая молекула capable of restoring caspofungin sensitivity, inhibits Yck2 киназы in C. albicans, originally discovered as an ингибитор of human p38α с IC50 of 150 n
GDC-0339 (GDC0339) is a novel малая молекула pan-Pim киназы ингибитор that was discovered as a potential treatment for multiple myeloma.
Proteasome-IN-4 is an excellent and non-covalent proteasome ингибитор (IC50=8.39 nM). Proteasome-IN-4 has мощный antiproliferative activities against RPMI-8226, MM-1S and MV-4-11 клетка lines. Proteas
Antiallergic agent-1, a Src-family киназы ингибитор, may serve as a new valuable lead compound for future antiallergic препарат discovery.
ARRY-797, also known as ARRY-371797, is a мощный and селективный p38α ингибитор (p38 mitogen-activated protein киназы ингибитор). ARRY-371797 Inhibits LPS-Induced IL-6 and in vivo Growth of RPMI-8226
MDR-652 is a nonpungent transient рецептор potential vanilloid 1 (TRPV1) агонист discovered to be a strong topical analgesic.
Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments, and eyedrops. The discovery of neomycin dates back to 1949. It was discovered in the lab of Selman
Setrobuvir (ANA-598) is an experimental препарат candidate For the treatment of hepatitis C. It was discovered at Anadys Pharmaceuticals. In 2011, Roche acquired Anadys in order to develop setrobuvir.
Kaitocephalin (PF 1191) is a non-селективный ionotropic glutamate рецептор (iGluR) антагонист, the first discovered natural toxin with protective properties against excitotoxic-death of cultured neuro
Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase ингибитор for U266, RPMI8226, and MM1.S cells с IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.