Биологическая активность
Trk-IN-10 (Compound 14j) is a мощный ингибитор of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a рецептор tyrosine киназы (RTK), tropomyosin рецептор киназы (Trk) is a key препарат target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity.
Оригинал на английском
Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity.
Химические свойства
- CAS №
- 2700265-61-6
- Брутто-формула
- C₂₀H₂₀FN₅O₃
- Мол. масса
- 397.40 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.