Биологическая активность
TQL-1055 is a semi-synthetic analog of the saponin adjuvant QS-21 (HY-101092) and can be used as a prophylactic vaccine adjuvant. TQL-1055 exhibits robust adjuvant activity for influenza antigens. TQL-1055 combined with the acellular pertussis vaccine (aP) shows good tolerance and enhances the антитело response to pertussis toxin (PT) in mice and rabbits. TQL-1055 is promising for research of chronic hepatitis B.
Оригинал на английском
TQL-1055 is a semi-synthetic analog of the saponin adjuvant QS-21 (HY-101092) and can be used as a prophylactic vaccine adjuvant. TQL-1055 exhibits robust adjuvant activity for influenza antigens. TQL-1055 combined with the acellular pertussis vaccine (aP) shows good tolerance and enhances the antibody response to pertussis toxin (PT) in mice and rabbits. TQL-1055 is promising for research of chronic hepatitis B.
Химические свойства
- CAS №
- 2095876-40-5
- Брутто-формула
- C₅₉H₉₅NO₂₀
- Мол. масса
- 1138.38 г/моль
- SMILES
- O[C@H]1[C@@]2(C(=O)O[C@H]3[C@@H]([C@H]([C@H]([C@@H](CO)O3)NC(CCCCCCCCCCC(=O)O)=O)O)O[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O[C@H]3[C@@H]([C@H]([C@@H](CO3)O)O)O)O)O)CCC(C)(C)C[C@H]2C2=CC[C@@H]3[C@@]4(C)CC[C@@H]([C@](C=O)(C)[C@@H]4CC[C@@]3(C)[C@]2(C)C1)O
- Синонимы
- Olean-12-en-28-oic acid, 3,16-dihydroxy-23-oxo-, O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-4-[(11-carboxy-1-oxoundecyl)amino]-4-deoxy-β-D-galactopyranosyl ester, (3β,4α,16α)-; 2095876-40-5; TQL-1055; Olean-12-en-28-oic acid, 3,16-dihydroxy-23-oxo-, O-beta-D-xylopyranosyl-(1-->4)-O-6-deoxy-alpha-L-mannopyranosyl-(1-->2)-4-[(11-carboxy-1-oxoundecyl)amino]-4-deoxy-beta-D-galactopyranosyl ester, (3beta,4alpha,16alpha)-; O-beta-D-Xylopyranosyl-(1-->4)-O-6-deoxy-alpha-L-mannopyranosyl-(1-->2)-4-[(11-carboxy-1-oxoundecyl)amino]-4-deoxy-beta-D-galactopyranosyl (3beta,4alpha,16alpha)-3,16-dihydroxy-23-oxoolean-12-en-28-oate и ещё 1
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.