Биологическая активность
Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine. Emavusertib mesylate is an orally active ингибитор for IRAK4 (IC50=57 nM) and FLT3. Emavusertib mesylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to клетка apoptosis. Emavusertib mesylate exhibits antitumor activity in mouse model.
Оригинал на английском
Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine. Emavusertib mesylate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib mesylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib mesylate exhibits antitumor activity in mouse model.
Химические свойства
- CAS №
- 71080-06-3
- Брутто-формула
- C₂₀H₂₄ClN₅S
- Мол. масса
- 401.96 г/моль
- SMILES
- CC1=NC2=C(C(/N=C(NC3CCCCC3)/NC4=NC=CS4)=C1)C=CC=C2.Cl
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.