Биологическая активность
STC-15 is a groundbreaking, orally bioavailable, highly селективный ингибитор of METTL3, an RNA methyltransferase enzyme that plays a critical role in regulating gene expression through N6-methyladenosine (m6A) modification of RNA. METTL3 is implicated in the pathogenesis of various cancers, including acute myeloid leukemia (AML) and solid tumors. STC-15 represents the first molecule specifically targeting an RNA methyltransferase enzyme to enter clinical development, marking a significant milestone in the field of epitranscriptomics and cancer therapy.
Оригинал на английском
STC-15 is a groundbreaking, orally bioavailable, highly selective inhibitor of METTL3, an RNA methyltransferase enzyme that plays a critical role in regulating gene expression through N6-methyladenosine (m6A) modification of RNA. METTL3 is implicated in the pathogenesis of various cancers, including acute myeloid leukemia (AML) and solid tumors. STC-15 represents the first molecule specifically targeting an RNA methyltransferase enzyme to enter clinical development, marking a significant milestone in the field of epitranscriptomics and cancer therapy.
Химические свойства
- CAS №
- 2648257-56-9
- Брутто-формула
- C₂₄H₂₅N₅O₂
- Мол. масса
- 415.49 г/моль
- SMILES
- C12C=CC=CN1C(=O)C=C(C(NCC1=CC3=C(C=C1)C=C(CNCC1CCC1)N3)=O)N=2
- Синонимы
- 4H-Pyrido[1,2-a]pyrimidine-2-carboxamide, N-[[2-[[(cyclobutylmethyl)amino]methyl]-1H-indol-6-yl]methyl]-4-oxo-; STC-15
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.