Биологическая активность
Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected клетка lines) induced by acetylcholine, nicotine, choline, and the a7-specific агонист PNU-282987. CTT2274 is composed of a prostate-specific membrane antigen (PSMA)-связывание scaffold, a biphenyl motif, a pH-sensitive phosphoramidate linker, and MMAE payload. CTT2274 shows селективный связывание to PSMA and delivers MMAE. CTT2274 inhibits prostate cancer.
Оригинал на английском
Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987. CTT2274 is composed of a prostate-specific membrane antigen (PSMA)-binding scaffold, a biphenyl motif, a pH-sensitive phosphoramidate linker, and MMAE payload. CTT2274 shows selective binding to PSMA and delivers MMAE. CTT2274 inhibits prostate cancer.
Химические свойства
- CAS №
- 1020634-41-6
- Брутто-формула
- C₂₄H₂₆N₄O₃
- Мол. масса
- 418.49 г/моль
- SMILES
- O=C1C2=CC(NC3CC4=C(C3)C=CC=C4)=CN=C2N(CC)C=C1C(N5CCOCC5)=O
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.