Биологическая активность
SIRT5 ингибитор 32 is an efficient, cellularly active малая молекула that targets SIRT5.SIRT5 ингибитор 32 inhibits клетка growth of SIRT5-dependent AML клетка lines SKM-1, OCIAML2 and MOLM-13 с IC50 of 9, 20, and 24 uM, respectively.SIRT5 ингибитор 32 is also shown to inhibit SIRT5 in HeLa cells by using an assay that produce in-клетка fluoresence in response to SIRT5 activity in the mitochondria.SIRT5 ингибитор 32 displays cytoselective toxicity towards SIRT5-dependent AML cells (SKM-1) over HEK293T cells in culture.
Оригинал на английском
SIRT5 inhibitor 32 is an efficient, cellularly active small molecule that targets SIRT5.SIRT5 inhibitor 32 inhibits cell growth of SIRT5-dependent AML cell lines SKM-1, OCIAML2 and MOLM-13 with IC50 of 9, 20, and 24 uM, respectively.SIRT5 inhibitor 32 is also shown to inhibit SIRT5 in HeLa cells by using an assay that produce in-cell fluoresence in response to SIRT5 activity in the mitochondria.SIRT5 inhibitor 32 displays cytoselective toxicity towards SIRT5-dependent AML cells (SKM-1) over HEK293T cells in culture.
Химические свойства
- Брутто-формула
- C₄₀H₅₅FN₁₀O₆S₂
- Мол. масса
- 855.06 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.