Биологическая активность
SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem клетка-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with препарат resistant tumorigenic CD133+/CD44+ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with препарат resistance, such as colon, pancreatic and renal cancers.
Оригинал на английском
SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133+/CD44+ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers.
Химические свойства
- CAS №
- 178250-23-2
- Брутто-формула
- C₄₅H₅₉NO₁₅
- Мол. масса
- 853.95 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.