Биологическая активность
Salinomycin is an antibacterial and coccidiostat ionophore agent. Salinomycin suppresses T24 cells by regulating KDM1A and the unfolded protein response pathway. Salinomycin alleviates osteoarthritis progression via inhibiting Wnt/β-catenin signaling. Vitamin D3 and Salinomycin synergy in MCF-7 cells cause клетка death via endoplasmic reticulum stress in monolayer and 3D клетка culture. Salinomycin induces клетка cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo,
Оригинал на английском
Salinomycin is an antibacterial and coccidiostat ionophore agent. Salinomycin suppresses T24 cells by regulating KDM1A and the unfolded protein response pathway. Salinomycin alleviates osteoarthritis progression via inhibiting Wnt/β-catenin signaling. Vitamin D3 and Salinomycin synergy in MCF-7 cells cause cell death via endoplasmic reticulum stress in monolayer and 3D cell culture. Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo,
Химические свойства
- CAS №
- 53003-10-4
- Брутто-формула
- C₄₂H₇₀O₁₁
- Мол. масса
- 751.01 г/моль
- SMILES
- O[C@H](C=C1)[C@](O[C@@]2(C)C3O[C@@H](C)[C@](CC)(O)CC3)(CC2)O[C@@]1([C@H](C)C[C@@H]4C)OC4[C@H](CC)C([C@H](C)[C@H](O)[C@H](C)C([C@@H](C)CC5)O[C@H]5[C@H](CC)C([O-])=O)=O.[Na+]
- Синонимы
- Procoxacin
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.