Биологическая активность
Ritlecitinib, also known as PF-06651600, is a мощный and селективный JAK3 ингибитор. PF-06651600 is a мощный and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific ингибитор PF-06651600 led to its evaluation in several human clinical studies. JAK3 was among the first of the JAKs targeted for therapeutic intervention due to the strong validation provided by human SCID patients displaying JAK3 deficiencies.
Оригинал на английском
Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific inhibitor PF-06651600 led to its evaluation in several human clinical studies. JAK3 was among the first of the JAKs targeted for therapeutic intervention due to the strong validation provided by human SCID patients displaying JAK3 deficiencies.
Химические свойства
- CAS №
- 2192215-81-7
- Брутто-формула
- C₂₂H₂₇N₅O₄S
- Мол. масса
- 457.55 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.