Биологическая активность
An anthelmintic effective agent for pinworms that shows to be a мощный ингибитор of Wnt signaling with EC50 of 10 nM; binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α киназы activity; inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation; also is a мощный ингибитор of HH signaling by reducing the stability of the Gli family of transcription factors.
Оригинал на английском
An anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM; binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity; inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation; also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.
Химические свойства
- CAS №
- 3546-41-6
- Брутто-формула
- C₂₆H₂₈N₃.₁/₂C₂₃H₁₄O₆
- Мол. масса
- 575.70 г/моль
- SMILES
- [O-]C(C1C(O)=C(CC2C3=CC=CC=C3C=C(C([O-])=O)C=2O)C2=C(C=CC=C2)C=1)=O.CN(C)C1=CC2C=CC(/C=C/C3=C(C)N(C4=CC=CC=C4)C(C)=C3)=[N+](C)C=2C=C1.CN(C)C1=CC2C=CC(/C=C/C3=C(C)N(C4=CC=CC=C4)C(C)=C3)=[N+](C)C=2C=C1
- Синонимы
- Pyrvinium embonate
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.