Биологическая активность
PNR-3-80 is a селективный Apoptotic endonuclease G (EndoG) ингибитор with an IC50 of 0.67 μM for EndoG over DNase I. PNR-3-80 does not have inhibitory activities for DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-80 has a мощный cytoprotective activity, and it significantly protects human prostate carcinoma cells from Cisplatin and Docetaxel-induced клетка death and represses Etoposide-induced DNA damage and autophagy. PNR-3-80 can be used for клетка injuries research.
Оригинал на английском
PNR-3-80 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC50 of 0.67 μM for EndoG over DNase I. PNR-3-80 does not have inhibitory activities for DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-80 has a potent cytoprotective activity, and it significantly protects human prostate carcinoma cells from Cisplatin and Docetaxel-induced cell death and represses Etoposide-induced DNA damage and autophagy. PNR-3-80 can be used for cell injuries research.
Химические свойства
- CAS №
- 1424353-63-8
- Брутто-формула
- C₂₄H₁₄ClN₃O₃S
- Мол. масса
- 459.90 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.