Биологическая активность
Pelcitoclax, also known as APG 1252 and BM1251, is a мощный and селективный Bcl-2/Bcl-XL ингибитор. APG-1252 A Bcl-2 homology (BH)-3 mimetic and селективный ингибитор of the anti-apoptotic proteins B-клетка lymphoma 2 (Bcl-2) and Bcl-XL, with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2/Bcl-XL ингибитор APG-1252 specifically binds to and inhibits the activity of the pro-survival proteins Bcl-2 and Bcl-XL. This restores apoptotic processes and inhibits клетка proliferation in Bcl-2/Bcl-XL-dependent tumor cells.
Оригинал на английском
Pelcitoclax, also known as APG 1252 and BM1251, is a potent and selective Bcl-2/Bcl-XL inhibitor. APG-1252 A Bcl-2 homology (BH)-3 mimetic and selective inhibitor of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL, with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2/Bcl-XL inhibitor APG-1252 specifically binds to and inhibits the activity of the pro-survival proteins Bcl-2 and Bcl-XL. This restores apoptotic processes and inhibits cell proliferation in Bcl-2/Bcl-XL-dependent tumor cells.
Химические свойства
- CAS №
- 1619923-36-2
- Брутто-формула
- C₅₇H₆₆ClF₄N₆O₁₁PS₄
- Мол. масса
- 1281.85 г/моль
- SMILES
- ClC1C([H])=C([H])C(=C([H])C=1[H])C1=C(C2C([H])=C(C([H])=C(C=2[H])N2C([H])([H])C([H])([H])N(C3C([H])=C([H])C(=C([H])C=3[H])N([H])S(C3C([H])=C([H])C(=C(C=3[H])S(C(F)(F)F)(=O)=O)N([H])[C@@]([H])(C([H])([H])SC3C([H])=C([H])C([H])=C([H])C=3[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C3([H])[H])(=O)=O)C([H])([H])C2([H])[H])F)C(=C(C([H])([H])[H])N1C([H])(C([H])([H])[H])C([H])([H])[H])S(C([H])([H])[H])(=O)=O
- Синонимы
- Pelcitoclax; 317UBD60ML; Pelcitoclax [INN]; APG1252; APG 1252 [WHO-DD] и ещё 2
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.