Биологическая активность
PCH-1 is a мощный antitumor agent that disrupts microtubule assembly, leading to cancer клетка death, interacts vinblastine связывание site on tubulin; PCH-1 exhibits the strongest cytotoxic activity through interaction with tubulin, leading to клетка cycle arrest and induction of apoptosis. PCH-1 efficiently inhibits the growth of NSCLC cancer клетка lines at micromolar concentrations (A-549 IC50=4.32 uM, H226 IC50=4.69 uM), and non-toxic to normal cells.
Оригинал на английском
PCH-1 is a potent antitumor agent that disrupts microtubule assembly, leading to cancer cell death, interacts vinblastine binding site on tubulin; PCH-1 exhibits the strongest cytotoxic activity through interaction with tubulin, leading to cell cycle arrest and induction of apoptosis. PCH-1 efficiently inhibits the growth of NSCLC cancer cell lines at micromolar concentrations (A-549 IC50=4.32 uM, H226 IC50=4.69 uM), and non-toxic to normal cells.
Химические свойства
- Брутто-формула
- C₂₀H₂₀N₂O₅
- Мол. масса
- 368.39 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.