Биологическая активность
PARPYnD is the first клетка-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 ингибитор AZ9482.PARPYnD is a robust tool for profiling PARP1/2 and is used to profile clinical PARP ингибитор olaparib, identifying several novel off-target proteins.PARPYnD can enrich recombinant PARP6 spiked into клеточный lysates and inhibits PARP6 in клетка-free assays, it does not label PARP6 in intact cells.PARPYnD inhibits PARP1/2/6 с IC50 of 38/6/230 nM, respectively.
Оригинал на английском
PARPYnD is the first cell-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 inhibitor AZ9482.PARPYnD is a robust tool for profiling PARP1/2 and is used to profile clinical PARP inhibitor olaparib, identifying several novel off-target proteins.PARPYnD can enrich recombinant PARP6 spiked into cellular lysates and inhibits PARP6 in cell-free assays, it does not label PARP6 in intact cells.PARPYnD inhibits PARP1/2/6 with IC50 of 38/6/230 nM, respectively.
Химические свойства
- CAS №
- 2561483-27-8
- Брутто-формула
- C₃₄H₃₁N₉O₃
- Мол. масса
- 613.68 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.