Биологическая активность
Nisoxetine acts as a highly селективный and мощный noradrenaline transporter (NET) антагонист, exhibiting a связывание affinity (Kd) of 0.76 nM. In addition to its antidepressant properties, nisoxetine functions as a local anesthetic by inhibiting voltage-gated sodium channels. This dual pharmacological activity makes it a compound of interest for both neurological and pain management research.
Оригинал на английском
Nisoxetine acts as a highly selective and potent noradrenaline transporter (NET) antagonist, exhibiting a binding affinity (Kd) of 0.76 nM. In addition to its antidepressant properties, nisoxetine functions as a local anesthetic by inhibiting voltage-gated sodium channels. This dual pharmacological activity makes it a compound of interest for both neurological and pain management research.
Химические свойства
- CAS №
- 53179-07-0
- Брутто-формула
- C₁₇H₂₁NO₂
- Мол. масса
- 271.35 г/моль
- SMILES
- CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC
- Синонимы
- Benzenepropanamine, g-(2-methoxyphenoxy)-N-methyl-; 3-(2-Methoxyphenoxy)-N-methyl-3-phenyl-1-propanamine; [3H]-Nifedipine; [3H]-Nisoxetine; 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine-dicarboxylic acid dimethyl ester и ещё 88
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.