Биологическая активность
Nimotuzumab is a humanized IgG1 моноклональный антитело targeting EGFR with a KD of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the связывание to its ligands. Nimotuzumab, a strong antitumor agent, is cytolytic on target tumors by its capacity to cause антитело dependent клетка mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).
Оригинал на английском
Nimotuzumab is a humanized IgG1 monoclonal antibody targeting EGFR with a KD of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab, a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).
Химические свойства
- CAS №
- 780758-10-3 pH value: Corresponds to reference standard: PASS Non-reduced CE-SDS: >95% SEC-HPLC: >95% Isoelectric Point: Corresponds to reference standard Osmolality: Corresponds to reference standard: PASS Peptide mapping: Corresponds to reference standard: PASS N-terminal sequence: Corresponds to reference standard: PASS
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.