Биологическая активность
Naftifine is an allylamine antifungal препарат for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces.
Оригинал на английском
Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces.
Химические свойства
- CAS №
- 65473-14-5
- Брутто-формула
- C₂₁H₂₂ClN
- Мол. масса
- 323.86 г/моль
- SMILES
- Cl.N(C)(C/C=C/C1C=CC=CC=1)CC1=CC=CC2C=CC=CC1=2
- Синонимы
- Naftifine hydrochloride; (E)-N-Cinnamyl-N-methyl(1-naphthylmethyl)amine hydrochloride; N-trans-Cinnamyl-N-methyl-(1-naphthylmethyl)amine Hydrochloride; Naftifine (hydrochloride); Naftifine Hydrochlor и ещё 91
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.