Биологическая активность
Lintuzumab (HUM-195) is an anti-CD33 humanized моноклональный антитело. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor клетка killing through антитело-dependent клеточный cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR? and MDR+ AML клетка lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice.
Оригинал на английском
Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR? and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice.
Химические свойства
- CAS №
- 166089-32-3 pH value: Corresponds to reference standard: PASS Non-reduced CE-SDS: >95% SEC-HPLC: >95% Isoelectric Point: Corresponds to reference standard Osmolality: Corresponds to reference standard: PASS Peptide mapping: Corresponds to reference standard: PASS N-terminal sequence: Corresponds to reference standard: PASS
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.