Биологическая активность
K306 is a малая молекула агонист that specifically targets SH2-containing 5' inositol phosphatase 1 (SHIP1), an enzyme involved in regulating клеточный signaling pathways. SHIP1 is a липид phosphatase that hydrolyzes the 5' phosphate of phosphatidylinositol-3,4,5-trisphosphate (PIP3), converting it to phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2). This activity modulates the PI3K (phosphoinositide 3-киназы) signaling pathway, which is critical for клетка survival, proliferation, and immune responses.
Оригинал на английском
K306 is a small molecule agonist that specifically targets SH2-containing 5' inositol phosphatase 1 (SHIP1), an enzyme involved in regulating cellular signaling pathways. SHIP1 is a lipid phosphatase that hydrolyzes the 5' phosphate of phosphatidylinositol-3,4,5-trisphosphate (PIP3), converting it to phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2). This activity modulates the PI3K (phosphoinositide 3-kinase) signaling pathway, which is critical for cell survival, proliferation, and immune responses.
Химические свойства
- CAS №
- 1184987-29-8
- Брутто-формула
- C₁₇H₂₀FN₃O₅S₄
- Мол. масса
- 493.60 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.