Биологическая активность
Iso-A11B5C1 is an ионизируемый липид. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available липид SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused мощный клеточный immune responses, even with limited expression observed in lymph nodes.
Оригинал на английском
Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes.
Химические свойства
- Брутто-формула
- C₄₁H₇₉N₃O₃
- Мол. масса
- 663.10 г/моль
- SMILES
- CCCCCCCC/C=C\CCCCCCCCNC(=O)C(CCCCCOC(=O)CCC(C)CCCCC)NCCN1CCCC1
- Синонимы
- IsoA11B5C1
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 1 года -20°C Publication: Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects--Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):Jingan Chen ,Bowen Li
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.