Биологическая активность
HuR ингибитор KH-3 is a малая молекула, селективный inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer клетка growth in vitro and in vivo.KH-3 inhibits breast cancer клетка invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer клетка invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.
Оригинал на английском
HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.
Химические свойства
- CAS №
- 1215115-03-9
- Брутто-формула
- C₂₁H₂₂N₂O₄S₂
- Мол. масса
- 430.54 г/моль
- SMILES
- C(NO)(=O)/C=C/C1SC2=CC=C(NS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)C=C2C=1
- Синонимы
- KH-3; (2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.