Биологическая активность
GSK-229423 is a novel bacterial topoisomerase ингибитор that shows мощный inhibition of supercoiling by DNA gyrase from S. aureus с IC50 of 14 nM; displays approximately 70 times more мощный against S. aureus DNA gyrase than NXL101; has мощный antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.
Оригинал на английском
GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM; displays approximately 70 times more potent against S. aureus DNA gyrase than NXL101; has potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.
Химические свойства
- CAS №
- 1352149-24-6
- Брутто-формула
- C₂₆H₂₉N₅Os
- Мол. масса
- 459.61 г/моль
- Синонимы
- GSK229423
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.