Биологическая активность
FP802 is a novel малая молекула with significant neuroprotective properties, specifically designed to target and disrupt the TwinF interface within the NMDAR/TRPM4 death signaling complex. This unique mechanism allows FP802 to selectively eliminate extrasynaptic NMDAR (eNMDAR)-mediated toxicity, which is implicated in various neurodegenerative diseases, while preserving the essential physiological functions of synaptic NMDARs. This selectivity makes FP802 a promising therapeutic candidate for conditions involving excitotoxicity and neuronal клетка death.
Оригинал на английском
FP802 is a novel small molecule with significant neuroprotective properties, specifically designed to target and disrupt the TwinF interface within the NMDAR/TRPM4 death signaling complex. This unique mechanism allows FP802 to selectively eliminate extrasynaptic NMDAR (eNMDAR)-mediated toxicity, which is implicated in various neurodegenerative diseases, while preserving the essential physiological functions of synaptic NMDARs. This selectivity makes FP802 a promising therapeutic candidate for conditions involving excitotoxicity and neuronal cell death.
Химические свойства
- CAS №
- 61694-81-3
- Брутто-формула
- C₁₁H₁₇ClN₂
- Мол. масса
- 212.72 г/моль
- SMILES
- CCN(CCN)CC1=CC(=CC=C1)Cl
- Синонимы
- 1,2-Ethanediamine, N-[(3-chlorophenyl)methyl]-N-ethyl-; N'-[(3-chlorophenyl)methyl]-N'-ethylethane-1,2-diamine; AKOS026290481; N*1*-(3-Chloro-benzyl)-N*1*-ethyl-ethane-1,2-diamine; N-(3-Chlorobenzyl)-N-ethyl-1,2-ethanediamine и ещё 9
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.