Биологическая активность
FFA2R агонист 58 is a мощный, allosteric FFAR2 (GPR43) агонист/modulator.FFA2R агонист 58 functions as a positive/priming modulator in these cells by turning the natural FFA2R агонист acetate into a мощный activator of the neutrophil NADPH-oxidase.FFA2R агонист 58 lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.FFA2R агонист 58 significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells.
Оригинал на английском
FFA2R agonist 58 is a potent, allosteric FFAR2 (GPR43) agonist/modulator.FFA2R agonist 58 functions as a positive/priming modulator in these cells by turning the natural FFA2R agonist acetate into a potent activator of the neutrophil NADPH-oxidase.FFA2R agonist 58 lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.FFA2R agonist 58 significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells.
Химические свойства
- CAS №
- 1208552-99-1
- Брутто-формула
- C₂₁H₂₁ClN₂Os
- Мол. масса
- 384.92 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.