Биологическая активность
FAPI-4 is a мощный FAP ингибитор with significant applications in cancer research and diagnostics. Its radiolabeled form, ⁶⁸Ga-FAPI-4, is a promising PET/CT imaging agent for visualizing FAP-expressing tumors with excellent tumor-to-background contrast. This makes it a valuable tool for cancer diagnosis, staging, treatment monitoring, and therapeutic development, particularly in cancers with a prominent stromal component.
Оригинал на английском
FAPI-4 is a potent FAP inhibitor with significant applications in cancer research and diagnostics. Its radiolabeled form, ⁶⁸Ga-FAPI-4, is a promising PET/CT imaging agent for visualizing FAP-expressing tumors with excellent tumor-to-background contrast. This makes it a valuable tool for cancer diagnosis, staging, treatment monitoring, and therapeutic development, particularly in cancers with a prominent stromal component.
Химические свойства
- CAS №
- 2374782-02-0
- Брутто-формула
- C₄₀H₅₄F₂N₁₀O₁₀
- Мол. масса
- 872.91 г/моль
- SMILES
- FC1(C([H])([H])N(C(C([H])([H])N([H])C(C2C([H])=C([H])N=C3C([H])=C([H])C(=C([H])C=23)OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C3([H])[H])=O)C([H])([H])C2([H])[H])=O)=O)[C@]([H])(C#N)C1([H])[H])F
- Синонимы
- FAPI-4; (S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinoli
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.