Биологическая активность
Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of клетка wall metabolism, osmotic stress responses and sporulation. Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2]. Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3]. Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].
Оригинал на английском
Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2]. Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3]. Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].
Химические свойства
- CAS №
- 54447-84-6
- Брутто-формула
- C₂₀H₂₄N₁₀O₁₂P₂
- Мол. масса
- 658.41 г/моль
- SMILES
- NC1=NC=NC2N([C@@H]3O[C@@H]4COP(O[C@@H]5[C@@H](COP(O[C@H]4[C@H]3O)(O)=O)O[C@@H](N3C=NC4C(=NC=NC3=4)N)[C@@H]5O)(O)=O)C=NC1=2
- Синонимы
- Cyclic di-3',5'-adenylate; c-Di-AMP; Cyclic-di-AMP; Cyclic diadenylate; Cyclic di-AMP и ещё 1
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.