Биологическая активность
BU72 is a highly мощный and long-acting агонист of μ and κ opioid receptors, and also has a partial агонист effect on δ opioid receptors (EC50 values are 0.054, 0.033, and 0.58 nM, respectively). BU72 has a strong and long-lasting analgesic effect, which is mainly mediated by μ opioid receptors. BU72 has a long-lasting activity and can partially reverse the analgesic effect of morphine. BU72 can be used in the study of opioid dependence.
Оригинал на английском
BU72 is a highly potent and long-acting agonist of μ and κ opioid receptors, and also has a partial agonist effect on δ opioid receptors (EC50 values are 0.054, 0.033, and 0.58 nM, respectively). BU72 has a strong and long-lasting analgesic effect, which is mainly mediated by μ opioid receptors. BU72 has a long-lasting activity and can partially reverse the analgesic effect of morphine. BU72 can be used in the study of opioid dependence.
Химические свойства
- CAS №
- 173265-76-4
- Брутто-формула
- C₂₈H₃₂N₂O₂
- Мол. масса
- 428.57 г/моль
- SMILES
- CO[C@@]12[C@](N[C@@H]3C4=CC=CC=C4)([H])[C@@](C5=CC(O)=CC=C5C[C@@]6([H])N7C)(CC7)C6(C=C2)CC13C
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.