Биологическая активность
BMS-986172 is a highly мощный MGAT2 ингибитор that Achieved Targeted Efficacious Exposures at a L BMS-986172 showed on-target- and mechanism-based pharmacology. Moreover, its favorable pharmacokinetic (PK) profile and the lack of species variability in the glucuronidation potential resulted in a greater confidence level in the projection of a low dose for achieving targeted efficacious exposures in humans. Consistent with these projections.
Оригинал на английском
BMS-986172 is a highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a L BMS-986172 showed on-target- and mechanism-based pharmacology. Moreover, its favorable pharmacokinetic (PK) profile and the lack of species variability in the glucuronidation potential resulted in a greater confidence level in the projection of a low dose for achieving targeted efficacious exposures in humans. Consistent with these projections.
Химические свойства
- CAS №
- 1808258-99-2
- Брутто-формула
- C₂₄H₂₂F₇N₇O₃
- Мол. масса
- 589.47 г/моль
- SMILES
- FC1=C([C@]2(C(F)(F)F)CC(C3=NN(C=C3)CC4CC4)=C(C(N2)=O)N5N=NNC5=O)C=CC(OCCCC(F)(F)F)=C1
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.