Биологическая активность
BGP-15 is a novel poly(ADP-ribose) polymerase ингибитор - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. BGP-15 also inhibits caspase-independent programmed клетка death in acetaminophen-induced liver injury. Moreover, BGP-15 was found to prevent imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases.
Оригинал на английском
BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. BGP-15 also inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury. Moreover, BGP-15 was found to prevent imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases.
Химические свойства
- CAS №
- 66611-37-8
- Брутто-формула
- C₁₄H₂₄Cl₂N₄O₂
- Мол. масса
- 351.27 г/моль
- SMILES
- Cl[H].Cl[H].O([H])C([H])(C([H])([H])O/N=C(/C1=C([H])N=C([H])C([H])=C1[H])\N([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
- Синонимы
- N-(2-Hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide dihydrochloride; BGP-15 2HCl; (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide; N-(2-Hydroxy-3-(piperidin-1-yl)propoxy)-nicotinimidamide dihydrochloride; BGP 15 и ещё 9
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.