Bezuclastinib

Биологическая активность

Bezuclastinib (PLX 9486; CGT9486) is a мощный ингибитор of c-kit and c-kit D816V (0.0001 Chemicals Properties биологическая активность Related products COA MSDS Datasheet Cas No.: 1616385-51-3 Chemical Name: 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide Synonyms: 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide;Bezuclastinib;3,4-Dimethyl-N-(2-phenyl-1H-pyrrolo(2,3-b)pyridin-5-yl)-1H-pyrazole-5-carboxamide;3,4-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-5-carboxamide;2ROQ545LAG;CGT9486;PLX 9486 [WHO-DD];BDBM392363;3,4-dimethyl-N-(2-phenyl-1H- pyrrolo[2,3-b]pyridin-5-yl)-1H- pyrazole-5-carboxamide SMILES: O=C(C1C(C([H])([H])[H])=C(C([H])([H])[H])N([H])N=1)N([H])C1=C([H])N=C2C(=C1[H])C([H])=C(C1C([H])=C([H])C([H])=C([H])C=1[H])N2[H] Formula: C 19 H 17 N 5 O M.Wt: 331.3712 Purity: >98% Sotrage: 2 years -20°C порошок, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO Cat. No. Product name Field of application DC72747 Elenestinib Elenestinib (BLU-263) is a мощный and orally active tyrosine киназы ингибитор. Elenestinib has the potential for the research of systemic mastocytosis (SM). DC48359 Bezuclastinib Bezuclastinib (PLX 9486; CGT9486) is a мощный ингибитор of c-kit and c-kit D816V (0.0001 DC44837 M4205 M4205 is a c-KIT ингибитор, with an IC50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17. DC7219 OSI 930 OSI-930 is a мощный ингибитор of Kit, KDR and CSF-1R с IC50 of 80 nM, 9 nM and 15 nM, respectively; also мощный to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. DC10082 ISCK03 ISCK03 is a клетка-permeable ингибитор of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 µM. DC9585 c-Kit-IN-1(DCC-2618) DCC-2618 is a малая молекула ингибитор of c-Kit and PDGFR with IC50s of 6 nM/30 nM/13 nM for c-Kit/PDGFRα/PDGFRβ respectively. DC10530 BLU-285 (Avapritinib) BLU-285 is a мощный and селективный exon 17 mutant KIT киназы ингибитор с IC50 of 0.27 nM for KIT D816V. DC7324 Amuvatinib (MP-470) Amuvatinib (MP-470) is a мощный and multi-targeted ингибитор of c-Kit, PDGFRα and Flt3 с IC50 of 10 nM, 40 nM and 81 nM, respectively. Get Quote Product Name Applicant name Telephone Email address Requested quantity Organization name Additional Information Verification code Fill in verification code