Биологическая активность
Axitirome, also known as CGS26214, is a highly селективный thyromimetic and a synthetic cholesterol-lowering agent (HMG CoA reductase ингибитор) shown to be active in the rat, dog and monkey. CGS 26214 is a racemic compound, which is consisted of two equipotent chiral components CGS 28934(-) and CGS 28935(+). CGS 26214, virtually devoid of cardiovascular effects, has мощный cholesterol-lowering activity in several models, reduces post-prandial response to a fat load in rats and markedly lowers Lp(a) concentrations in monkeys.
Оригинал на английском
Axitirome, also known as CGS26214, is a highly selective thyromimetic and a synthetic cholesterol-lowering agent (HMG CoA reductase inhibitor) shown to be active in the rat, dog and monkey. CGS 26214 is a racemic compound, which is consisted of two equipotent chiral components CGS 28934(-) and CGS 28935(+). CGS 26214, virtually devoid of cardiovascular effects, has potent cholesterol-lowering activity in several models, reduces post-prandial response to a fat load in rats and markedly lowers Lp(a) concentrations in monkeys.
Химические свойства
- CAS №
- 156740-57-7
- Брутто-формула
- C₂₅H₂₄FNO₆
- Мол. масса
- 453.47 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.