Биологическая активность
Aurora/LIM киназы-IN-1 (Compound F114) is a мощный and dual ингибитор of aurora and lim киназы. Aurora kinases and lim kinases are involved in neoplastic клетка division and клетка motility, respectively. Aurora/LIM киназы-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM киназы-IN-1 is a promising new scaffold for dual aurora/lim киназы inhibitors that may be used in future препарат development efforts for GBM, and potentially other cancers.
Оригинал на английском
Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future drug development efforts for GBM, and potentially other cancers.
Химические свойства
- Брутто-формула
- C₁₆H₂₀N₆O
- Мол. масса
- 312.37 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.