Биологическая активность
Aurora киназы ингибитор-14 (Compound 79) is an orally active and highly селективный ингибитор of Aurora kinases с IC50 values of 0.5 nM and 1.2 nM for Aurora A and Aurora B, respectively. Aurora киназы ингибитор-14 binds to the ATP-связывание site of Aurora kinases to block chromosome segregation during mitosis and induce apoptosis in tumor cells. Aurora киназы ингибитор-14 is promising for research of various solid tumors and hematological malignancies, such as non-small клетка lung cancer, breast cancer, and acute myeloid leukemia.
Оригинал на английском
Aurora kinase inhibitor-14 (Compound 79) is an orally active and highly selective inhibitor of Aurora kinases with IC50 values of 0.5 nM and 1.2 nM for Aurora A and Aurora B, respectively. Aurora kinase inhibitor-14 binds to the ATP-binding site of Aurora kinases to block chromosome segregation during mitosis and induce apoptosis in tumor cells. Aurora kinase inhibitor-14 is promising for research of various solid tumors and hematological malignancies, such as non-small cell lung cancer, breast cancer, and acute myeloid leukemia.
Химические свойства
- CAS №
- 958226-81-8
- Брутто-формула
- C₂₈H₃₈F₃N₇O₂
- Мол. масса
- 561.64 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.