Биологическая активность
AT9283 is a multikinase ингибитор, is also a small-molecule ингибитор of several kinases with potential antineoplastic activity. Multikinase ингибитор AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus киназы 2) and the киназы BCR-ABL, which may result in the inhibition of клеточный division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a киназы that transduces signals from the single chain and IL-3 cytokine рецептор families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine киназы activity that is commonly found in CML.
Оригинал на английском
AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML.
Химические свойства
- CAS №
- 896466-04-9
- Брутто-формула
- C₁₉H₂₃N₇O₂
- Мол. масса
- 381.43 г/моль
- SMILES
- O1C([H])([H])C([H])([H])N(C([H])([H])C2C([H])=C([H])C3=C(C=2[H])N([H])C(C2=C(C([H])=NN2[H])N([H])C(N([H])C2([H])C([H])([H])C2([H])[H])=O)=N3)C([H])([H])C1([H])[H]
- Синонимы
- 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea; 1-cyclopropyl-3-[(3Z)-3-[5-(morpholin-4-ylmethyl)benzimidazol-2-ylidene]-1,2-dihydropyrazol-4-yl]urea; AT9283; AT-9283; AT-9283,AT 9283 и ещё 9
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.