Биологическая активность
AN12855 (AN-12855) is мощный, cofactor-independent M. tuberculosis InhA ингибитор, binds to and inhibits InhA с IC50 of 0.03 uM, shows мощный activity against whole-клетка M. tuberculosis H37Rv with IC90 of 0.09 uM; AN12855 demonstrates мощный activity against препарат-susceptible and препарат-resistant strains of M. tuberculosis, exhibits comparable efficacy to the frontline antitubercular препарат isoniazid (INH) in both acute and chronic models of TB infection with a lower potential for resistance development and shows in vitro activity against conventional KatG-mediated INH-resistant M. tuberculosis.
Оригинал на английском
AN12855 (AN-12855) is potent, cofactor-independent M. tuberculosis InhA inhibitor, binds to and inhibits InhA with IC50 of 0.03 uM, shows potent activity against whole-cell M. tuberculosis H37Rv with IC90 of 0.09 uM; AN12855 demonstrates potent activity against drug-susceptible and drug-resistant strains of M. tuberculosis, exhibits comparable efficacy to the frontline antitubercular drug isoniazid (INH) in both acute and chronic models of TB infection with a lower potential for resistance development and shows in vitro activity against conventional KatG-mediated INH-resistant M. tuberculosis.
Химические свойства
- Брутто-формула
- C₁₇H₁₅BF₃N₃O₅S
- Мол. масса
- 441.19 г/моль
- Синонимы
- AN-12855; AN 12855
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.