Биологическая активность
α-methyl Serotonin (maleate) is an агонист of serotonin (5-HT) receptors. It binds selectively to 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors over 5-HT1E receptors. It is also селективный for 5-HT2B and 5-HT2C receptors over 5-HT2A receptors. α-methyl Serotonin potentiates motor neuron depolarizations induced by NMDA in the presence of the NMDA рецептор антагонист memantine. It also increases dopamine release in a dose-dependent manner. α-methyl Serotonin increases systolic blood pressure and transiently increases heart rate.
Оригинал на английском
α-methyl Serotonin (maleate) is an agonist of serotonin (5-HT) receptors. It binds selectively to 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors over 5-HT1E receptors. It is also selective for 5-HT2B and 5-HT2C receptors over 5-HT2A receptors. α-methyl Serotonin potentiates motor neuron depolarizations induced by NMDA in the presence of the NMDA receptor antagonist memantine. It also increases dopamine release in a dose-dependent manner. α-methyl Serotonin increases systolic blood pressure and transiently increases heart rate.
Химические свойства
- Брутто-формула
- C₁₅H₁₈N₂O₅
- Мол. масса
- 306.32 г/моль
- SMILES
- OC1=CC=C2C(C(CC(C)N)=CN2)=C1.OC(/C=C\C(O)=O)=O
- Синонимы
- α-Me-5-HT, α-methyl Serotonin (maleate), α-Methyl-5-HT, α-Methyl-5-hydroxytryptamine, α-Methylserotonin
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.