Биологическая активность
Al-28 is a multi-ионизируемый aminolipid featuring a central amine and three identical disulfide-linked saturated side chains. The hydrophobic side chains are linked to the central structure by ester as well as disulfide bonds. Disulfide bonds are readily cleaved in the reducing environment of the клетка cytoplasm. ионизируемый lipids are typically used in the design of nucleic acid липид nanoparticles, as their pH-dependent positive charge stabilizes the anionic nucleic acids they encapsulate.
Оригинал на английском
Al-28 is a multi-ionizable aminolipid featuring a central amine and three identical disulfide-linked saturated side chains. The hydrophobic side chains are linked to the central structure by ester as well as disulfide bonds. Disulfide bonds are readily cleaved in the reducing environment of the cell cytoplasm. Ionizable lipids are typically used in the design of nucleic acid lipid nanoparticles, as their pH-dependent positive charge stabilizes the anionic nucleic acids they encapsulate.
Химические свойства
- Брутто-формула
- C₅₈H₁₁₅N₃O₆S₆
- Мол. масса
- 1143.00 г/моль
- SMILES
- CCCCCCCCCCCCSSCCOC(CCNCCCN(C)CCCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCC(OCCSSCCCCCCCCCCCC)=O)=O
- Синонимы
- BP-40351,Al28， Al 28
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.