Биологическая активность
Zidebactam, also known as WCK-5107, is a Beta lactamase ингибитор. Zidebactam is a novel ингибитор of PBP2 Showing мощный "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Zidebactam demonstrated specific high-affinity связывание to PBP2 of A. baumannii (0.01 μg/ml for both of the compounds). The MIC of zidebactam was >1,024 μg/ml for wild-type and multidrug-resistant Acinetobacter strains. Zidebactam is a PBP2 ингибитор that show a мощный β-lactam enhancer effect against A. baumannii, including a multidrug-resistant OXA-23-producing ST2 international clone.
Оригинал на английском
Zidebactam, also known as WCK-5107, is a Beta lactamase inhibitor. Zidebactam is a novel Inhibitor of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Zidebactam demonstrated specific high-affinity binding to PBP2 of A. baumannii (0.01 μg/ml for both of the compounds). The MIC of zidebactam was >1,024 μg/ml for wild-type and multidrug-resistant Acinetobacter strains. Zidebactam is a PBP2 inhibitor that show a potent β-lactam enhancer effect against A. baumannii, including a multidrug-resistant OXA-23-producing ST2 international clone.
Химические свойства
- CAS №
- 1436861-97-0
- Брутто-формула
- C₁₃H₂₁N₅O₇S
- Мол. масса
- 391.40 г/моль
- SMILES
- O=C(NNC([C@@H]1CC[C@@H]2C[N@]1C(N2OS(=O)(O)=O)=O)=O)[C@@H]3CCCNC3
- Синонимы
- WCK-5107; WCK 5107; WCK5107; Zidebactam
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- -20
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.