Биологическая активность
Tomelukast, also known as LY171883, is a leukotriene ингибитор. Tomelukast showed protective effects in traumatic shock. LY-171883 stimulates the activity of BK(Ca) channels in a manner unlikely to be linked to its blockade of leukotriene receptors or stimulation of peroxisome proliferator-activated receptors. The stimulatory effects on these channels may, at least in part, contribute to the underlying клеточный mechanisms by which LY-171883 affects neuronal or neuroendocrine function.
Оригинал на английском
Tomelukast, also known as LY171883, is a leukotriene inhibitor. Tomelukast showed protective effects in traumatic shock. LY-171883 stimulates the activity of BK(Ca) channels in a manner unlikely to be linked to its blockade of leukotriene receptors or stimulation of peroxisome proliferator-activated receptors. The stimulatory effects on these channels may, at least in part, contribute to the underlying cellular mechanisms by which LY-171883 affects neuronal or neuroendocrine function.
Химические свойства
- CAS №
- 88107-10-2
- Брутто-формула
- C₁₆H₂₂N₄O₃
- Мол. масса
- 318.38 г/моль
- SMILES
- CC(C1=CC=C(OCCCCC2=NN=NN2)C(CCC)=C1O)=O
- Синонимы
- Tomelukast; LY171883; LY-171883; LY 171883.
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.