Биологическая активность
Oliceridine, also known as TRV130, is a μ- opioid рецептор агонист, that is currently under evaluation in human clinical trials for the treatment of acute severe pain. It is a functionally селективный μ-opioid рецептор агонист developed by Trevena Inc. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less β-arrestin 2 recruitment and рецептор internalization, it displays less adverse effects than morphine. (http://en.wikipedia.org/wiki/TRV130).
Оригинал на английском
Oliceridine, also known as TRV130, is a μ- opioid receptor agonist, that is currently under evaluation in human clinical trials for the treatment of acute severe pain. It is a functionally selective μ-opioid receptor agonist developed by Trevena Inc. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less β-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine. (http://en.wikipedia.org/wiki/TRV130).
Химические свойства
- CAS №
- 1401031-39-7
- Брутто-формула
- C₂₂H₃₀N₂O₂S
- Мол. масса
- 386.55 г/моль
- Синонимы
- TRV130; TRV 130; TRV130; Oliceridine; Oliceridine HCl и ещё 1
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.