Биологическая активность
TCPOBOP is an агонист of the constitutive androstane рецептор (CAR) (EC50 = 20 nM). TCPOBOP enhances the nuclear рецептор CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct агонист of CAR. The most мощный known member of the phenobarbital-like class of CYP-inducing agents. TCPOBOP has been used for enhancing Mcl-1-Italics promoter functions in mouse hepatoma cells. TCPOBOP has also been used to study constitutive androstane рецептор(CAR)-induced gene expression in mouse hepatocytes.
Оригинал на английском
TCPOBOP is an agonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents. TCPOBOP has been used for enhancing Mcl-1-Italics promoter functions in mouse hepatoma cells. TCPOBOP has also been used to study constitutive androstane receptor(CAR)-induced gene expression in mouse hepatocytes.
Химические свойства
- CAS №
- 76150-91-9
- Брутто-формула
- C₁₆H₈Cl₄N₂O₂
- Мол. масса
- 402.05 г/моль
- SMILES
- ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1
- Синонимы
- TCPOBOP
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.