Биологическая активность
Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein киназы II (CaMKII; Km = 12 μM).1 Its sequence is derived from the phosphorylation site 2 on glycogen synthase, a target of CaMKII action.1 This peptide has been used as a probe to assay CaMKII activity; however, protein киназы C, CaMKV, Raf-1, and other kinases are also known to recognize syntide-2 as a substrate.
Оригинал на английском
Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).1 Its sequence is derived from the phosphorylation site 2 on glycogen synthase, a target of CaMKII action.1 This peptide has been used as a probe to assay CaMKII activity; however, protein kinase C, CaMKV, Raf-1, and other kinases are also known to recognize syntide-2 as a substrate.
Химические свойства
- Брутто-формула
- C₆₈H₁₂₂N₂₀O₁₈
- Мол. масса
- 1507.84 г/моль
- SMILES
- NCCCC[C@@H](C(O)=O)NC([C@H](CCCCN)NC(CNC([C@H]1N(C([C@H](CC(C)C)NC(CNC([C@H](C)NC([C@H](C(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H]2NCCC2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O
- Синонимы
- Syntide-2; Syntide 2; Syntide2; Pro-leu-ala-arg-thr-leu-ser-val-ala-gly-leu-pro-gly-lys-lys
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.