Биологическая активность
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable биологическая активность. Nevertheless, the salt form (Sanguinarine chloride) usually boasts enhanced water solubility and stability.
Оригинал на английском
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Sanguinarine chloride) usually boasts enhanced water solubility and stability.
Химические свойства
- CAS №
- 2447-54-3
- Брутто-формула
- C₂₀H₁₄NO₄
- Мол. масса
- 332.33 г/моль
- SMILES
- O1C([H])([H])OC2C([H])=C([H])C3C(C1=2)=C([H])[N+](C([H])([H])[H])=C1C2=C([H])C4=C(C([H])=C2C([H])=C([H])C1=3)OC([H])([H])O4
- Синонимы
- sanguinarine; 1,3)-Benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-; SANGUINARINE (RG); Sanguinarium и ещё 107
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 4°C for 1 года, -20°C for more than 2 года
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.