Биологическая активность
SR-33805 is a calcium channel антагонист potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered клетка shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein киназы A activity by SR-33805.
Оригинал на английском
SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR-33805.
Химические свойства
- CAS №
- 121346-32-5
- Брутто-формула
- C₃₂H₄₀N₂O₅S
- Мол. масса
- 564.74 г/моль
- SMILES
- O=S(C1=CC=C(OCCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1)(C(N3C)=C(C(C)C)C4=C3C=CC=C4)=O
- Синонимы
- SR-33805; SR 33805; SR33805
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.