Биологическая активность
Foropafant, also known as SR-27417; SR-27417A, is a мощный platelet activating factor (PAF) ингибитор potentially for the treatment of asthma and allergic rhinitis (AR). SR 27417 inhibits in a dose-dependent manner the hypotensive effect of PAF in rats. It protected rats with an ED50 value of 6 +/- 2 micrograms/kg (n = 6), when given i.v., 1 min before PAF administration. PAF plays a major role in anaphylactic shock. SR 27417 may be an effective prophylactic as well as a мощный curative препарат in this pathology.
Оригинал на английском
Foropafant, also known as SR-27417; SR-27417A, is a potent platelet activating factor (PAF) inhibitor potentially for the treatment of asthma and allergic rhinitis (AR). SR 27417 inhibits in a dose-dependent manner the hypotensive effect of PAF in rats. It protected rats with an ED50 value of 6 +/- 2 micrograms/kg (n = 6), when given i.v., 1 min before PAF administration. PAF plays a major role in anaphylactic shock. SR 27417 may be an effective prophylactic as well as a potent curative drug in this pathology.
Химические свойства
- CAS №
- 136468-36-5
- Брутто-формула
- C₂₈H₄₀N₄S
- Мол. масса
- 464.72 г/моль
- SMILES
- CC(C1=C(C2=CSC(N(CC3=CC=CN=C3)CCN(C)C)=N2)C(C(C)C)=CC(C(C)C)=C1)C
- Синонимы
- SR-27417; SR 27417; SR27417; SR-27417A; Foropafant.
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.