Биологическая активность
SJB2-043 is an ингибитор of the native USP1/UAF1 complex с IC50 of 544 nM.SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of ингибитор of DNA-связывание-1 (ID1) protein in the K562 cells at a micromolar препарат concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner.
Оригинал на английском
SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM.SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner.
Химические свойства
- CAS №
- 63388-44-3
- Брутто-формула
- C₁₇H₉NO₃
- Мол. масса
- 275.26 г/моль
- SMILES
- O1C(C2C([H])=C([H])C([H])=C([H])C=2[H])=NC2C(C3=C([H])C([H])=C([H])C([H])=C3C(C1=2)=O)=O
- Синонимы
- SJB2-043; 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione; 2-PHENYLNAPHTHO[2,3-D]OXAZOLE-4,9-DIONE; C17H9NO3; SJB2 043 и ещё 80
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.