Биологическая активность
SHR0302 is a мощный and orally active all members of the JAK family ингибитор, particularly JAK1. The selectivity of SHR0302 for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2. SHR0302 inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. SHR0302 has anti-proliferative and anti-inflammatory effects.
Оригинал на английском
SHR0302 is a potent and orally active all members of the JAK family inhibitor, particularly JAK1. The selectivity of SHR0302 for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2. SHR0302 inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. SHR0302 has anti-proliferative and anti-inflammatory effects.
Химические свойства
- CAS №
- 1445987-21-2
- Брутто-формула
- C₁₈H₂₂N₈O₂S
- Мол. масса
- 414.49 г/моль
Хранение и физические свойства
- Условия хранения
- порошок -20°C 3 года 4°C 2 года In solvent -80°C 6 мес. -20°C 1 мес.
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.