Биологическая активность
Flutamide, also known as SCH13521, is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more мощный active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone связывание at androgen receptors, forming inactive complexes which cannot translocate into the клетка nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor клетка growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Оригинал на английском
Flutamide, also known as SCH13521, is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Химические свойства
- CAS №
- 13311-84-7
- Брутто-формула
- C₁₁H₁₁F₃N₂O₃
- Мол. масса
- 276.21 г/моль
- SMILES
- CC(C)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O
- Синонимы
- SCH13521; SCH-13521; SCH 13521; Flucinom; Flugerel и ещё 22
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.