Биологическая активность
(S)-AM1241 binds to cannabinoid (CB) receptors and is селективный for CB2 over CB1. (S)-1241 acts as an агонист at human, rat, and mouse CB2 receptors but shows greater activity at human CB2 than at rat and mouse CB2 receptors. Similar to the racemate AM1241, (S)-AM1241 produces antinociception to thermal pain but not mechanical pain in rats. The pain-reducing effect of (S)-AM1241 is blocked by the CB2-specific ингибитор SR 144528 but not by either the CB1-селективный ингибитор rimonabant or the opioid рецептор blocker naloxone
Оригинал на английском
(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for CB2 over CB1. (S)-1241 acts as an agonist at human, rat, and mouse CB2 receptors but shows greater activity at human CB2 than at rat and mouse CB2 receptors. Similar to the racemate AM1241, (S)-AM1241 produces antinociception to thermal pain but not mechanical pain in rats. The pain-reducing effect of (S)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone
Химические свойства
- Брутто-формула
- C₂₂H₂₂In₃O₃
- Мол. масса
- 503.34 г/моль
- SMILES
- CN1CCCC[C@H]1Cn2cc(c3c2cccc3)C(=O)c4cc(ccc4I)[N+](=O)[O-]
- Синонимы
- AM-1241, (S)-; (S)-AM1241; (S)-AM-1241
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.